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KMID : 0385019950110020175
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Korean Journal of Laboratory Animal Science
1995 Volume.11 No. 2 p.175 ~ p.182
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The Study on Four-week Intravenous toxicity of Erythropoietin in Rabbits
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이영순
조재진/서광원/남기환/김영석/남정석/미우라 마사야/제정환/이석만
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Abstract
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Abstract :
@EN The 4-week toxicity of erythropoietin was investigated using New Zealand White rabbits according to the established regulation of Korean National Institute of Safety Research. Rabbits were administered intravenously seven days per week for 28
days
with dosages of 0, 80, 240 and 720U/kg B.W./day.
Animals administered with erythropoietin showed no significant changes of body weight, water consumption and feed consumption, and no clinical signs and death. They were not significantly different from the control group in hematological and
serum
biochemical analysis, urinalysis, prothrombin time and partial thromboplastin time.
In this study, we concluded that EPO had no toxic effect in the New Zealand White rabbits when they were administered intravenously below 720U/kg B. W./day for four weeks.
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KEYWORD
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